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Article

The prognostic impact of c-KIT mutation in systemic mastocytosis associated with acute myeloid leukaemia patients.

Leukemia research - 1 Aug 2013

Won Dahae, Chi Hyun-Sook, Shim Hyoeun, Jang Seongsoo, Park Chan-Jeoung, Lee Je-Hwan

Abstract excerpt

We evaluate the haematopathologic features of systemic mastocytosis associated with acute myeloid leukaemia (SM-AML) and the prognostic role of c-KIT mutation. Total 11 patients were enrolled. Cytochemistry using toluidine blue and tryptase was positive, as was immunohistochemistry for CD117 and CD25 on clustered mast cells; however, CD2 was expressed in only nine cases. In 10 cases, RUNX1-RUNX1T1 fusion gene was...

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Topics

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Share to CD2 Antigens
Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Leukemia, Myeloid

Share to Mast Cells

Share to Mastocytosis, Systemic

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Source

Identifiers

PMID: 23683787
DOI: 10.1016/j.leukres.2013.04.020

Genes

KIT
RUNX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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