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Article

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm.

Haematologica - 1 Jun 2017

Jawhar Mohamad, Schwaab Juliana, Meggendorfer Manja, Naumann Nicole, Horny Hans-Peter, Sotlar Karl, Haferlach Torsten, Schmitt Karla, Fabarius Alice, Valent Peter, Hofmann Wolf-Karsten, Cross Nicholas C P, Metzgeroth Georgia, Reiter Andreas

Abstract excerpt

Mast cell leukemia is a rare variant of advanced systemic mastocytosis characterized by at least 20% of mast cells in a bone marrow smear. We evaluated clinical and molecular characteristics of 28 patients with (n=20, 71%) or without an associated hematologic neoplasm. De novo mast cell leukemia was diagnosed in 16 of 28 (57%) patients and secondary mast cell leukemia evolving from other advanced systemic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28255023
DOI: 10.3324/haematol.2017.163964
PMCID: PMC5451335

Genes

ASXL1
KIT
RUNX1
SRSF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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