Article
Clinical manifestations of highly prevalent corticosteroid-binding globulin mutations in a village in southern Italy.
The Journal of clinical endocrinology and metabolism - 1 Oct 2011
Cizza Giovanni, Bernardi Livia, Smirne Nicoletta, Maletta Raffaele, Tomaino Carmine, Costanzo Angela, Gallo Maura, Lewis John G, Geracitano Silvana, Grasso Maria Beatrice, Potenza Giuseppe, Monteleone Cosimo, Brancati Giacomino, Ho Jui T, Torpy David J, Bruni Amalia C
Abstract excerpt
CONTEXT: Corticosteroid-binding globulin (CBG) is the binding protein for cortisol. Rare kindreds with CBG mutations reducing CBG levels or altering binding affinity have been described, along with clinical manifestations encompassing fatigue, chronic pain, and hypotension. The largest kindred, exhibiting two mutations (null and Lyon) were Australian immigrants from Italy. OBJECTIVE: Our objective was to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.