Article
Pleiotropic mutations are subject to strong stabilizing selection.
Genetics - 1 Jul 2014
McGuigan Katrina, Collet Julie M, Allen Scott L, Chenoweth Stephen F, Blows Mark W
Abstract excerpt
The assumption that pleiotropic mutations are more deleterious than mutations with more restricted phenotypic effects is an important premise in models of evolution. However, empirical evidence supporting this assumption is limited. Here, we estimated the strength of stabilizing selection on mutations affecting gene expression in male Drosophila serrata. We estimated the mutational variance (VM) and the standing...
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