Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

doi:10.1016/j.cmet.2016.04.016

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Article

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Cell metabolism - 14 Jun 2016

Ducker Gregory S, Chen Li, Morscher Raphael J, Ghergurovich Jonathan M, Esposito Mark, Teng Xin, Kang Yibin, Rabinowitz Joshua D

Abstract excerpt

One-carbon (1C) units for purine and thymidine synthesis can be generated from serine by cytosolic or mitochondrial folate metabolism. The mitochondrial 1C pathway is consistently overexpressed in cancer. Here, we show that most but not all proliferating mammalian cell lines use the mitochondrial pathway as the default for making 1C units. Clustered regularly interspaced short palindromic repeats...

Topics

Aminoimidazole Carboxamide
CRISPR-Cas Systems
Carbon
Cell Compartmentation
Cell Proliferation
Colonic Neoplasms
Cytosol
Folic Acid
Formates
Gene Knockout Techniques
Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycine

Glycine Hydroxymethyltransferase

HCT116 Cells

HEK293 Cells

Humans

Leucovorin

Metabolic Networks and Pathways

Source

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Identifiers

PMID: 27211901
DOI: 10.1016/j.cmet.2016.04.016
PMCID: PMC4909566

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