Article

Mitochondrial one-carbon enzyme MTHFD1L sustains stemness and metastatic progression in breast cancer

2026-06-19

Abstract excerpt

One-carbon (1C) metabolism is frequently upregulated in cancer to support anabolic growth and nucleotide biosynthesis. However, the contribution of mitochondrial 1C metabolism to cancer stemness and metastatic progression remains incompletely understood. Here, we identify methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L), a mitochondrial 1C metabolic enzyme, as a critical regulator of breast cancer stemness...

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Literature Corpus work: 15a4f7e4-9575-54d8-95f7-88d33575d75a
DOI: 10.64898/2026.06.18.732629

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