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Article

PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target.

Cell death & disease - 11 Oct 2023

Singh Shaifali, Yeat Nai Yang, Wang Ya-Ting, Lin Shu-Yu, Kuo I-Ying, Wu Kuen-Phon, Wang Won-Jing, Wang Wen-Ching, Su Wu-Chou, Wang Yi-Ching, Chen Ruey-Hwa

Abstract excerpt

Aberrant overexpression or activation of EGFR drives the development of non-small cell lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by secondary EGFR mutations or c-MET amplification/activation remains as a major hurdle for NSCLC treatment. We previously identified WDR4 as a substrate adaptor of Cullin 4 ubiquitin ligase and an association of WDR4 high expression with poor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37821451
DOI: 10.1038/s41419-023-06201-4
PMCID: PMC10567730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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