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Article

Progress and challenges for treating Type 1 diabetes.

Journal of autoimmunity - 1 Jul 2016

Garyu Justin W, Meffre Eric, Cotsapas Chris, Herold Kevan C

Abstract excerpt

It has been more than 30 years since the initial trials of Cyclosporin A to treat patients with new onset Type 1 diabetes (T1D). Since that time, there have been insights into genetic predisposition to the disease, the failures of immune tolerance, and mechanisms that cause the immune mediated β cell destruction. The genetic loci associated affect lymphocyte development and tolerance mechanisms. Discoveries...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Models, Genetic

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Source

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Identifiers

PMID: 27210268
DOI: 10.1016/j.jaut.2016.04.004
PMCID: PMC4903889

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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