Article
Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.
Rheumatic diseases clinics of North America - 1 Nov 2014
Simmons Kimber, Michels Aaron W
Abstract excerpt
Type 1 diabetes (T1D) is a chronic autoimmune disorder resulting from immune-mediated destruction of insulin-producing beta cells within the pancreatic islets. Prediction of T1D is now possible, as having 2 or more islet autoantibodies confers a 100% risk of diabetes development. With the ability to predict disease development, clinical trials to prevent diabetes onset have been completed and are currently under...
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