Article
Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms.
Atherosclerosis - 1 Sept 2011
Roberts Rebecca L, Van Rij Andre M, Phillips L Vicky, Young Sarah, McCormick Sally P A, Merriman Tony R, Jones Gregory T
Abstract excerpt
OBJECTIVE: Cholesterol crystals have been shown to cause inflammation, and ultimately atherosclerotic lesions through the activation of the NLRP3 inflammasome. As cholesterol crystals have also been found in the walls of patients with abdominal aortic aneurysms (AAA), it is possible that the NLRP3 inflammasome is involved in AAA and genetic variability within this protein complex could alter disease risk. The...
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