Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma.

PLoS genetics - 1 May 2016

Lin Yung-Feng, Li Ling-Hui, Lin Chih-Hung, Tsou Mei-Hua, Chuang Ming-Tai Kiffer, Wu Keh-Ming, Liao Tsai-Lien, Li Jian-Chiuan, Wang Wei-Jie, Tomita Angela, Tomita Beverly, Huang Shiu-Feng, Tsai Shih-Feng

Abstract excerpt

In an effort to identify the functional alleles associated with hepatocellular carcinoma (HCC), we investigated 152 genes found in the 4q21-25 region that exhibited loss of heterozygosity (LOH). A total of 2,293 pairs of primers were designed for 1,449 exonic and upstream promoter regions to amplify and sequence 76.8-114 Mb on human chromosome 4. Based on the results from analyzing 12 HCC patients and 12 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Intercellular Signaling Peptides and Proteins

Share to Liver Neoplasms

Share to Loss of Heterozygosity

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 27203079
DOI: 10.1371/journal.pgen.1006051
PMCID: PMC4874628

Genes

DKK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma.PMID 27203079Read ↗

Intron retention by a novel intronic mutation in DKC1 gene caused recurrent still birth and early death in a Chinese family.Semantic proximity Read ↗

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.Semantic proximity Read ↗

Alternative splicing and mutation status of CHEK2 in stage III breast cancer.Semantic proximity Read ↗

Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.Semantic proximity Read ↗

Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma.Semantic proximity Read ↗

Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.Semantic proximity Read ↗

Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.Semantic proximity Read ↗

Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients.Semantic proximity Read ↗

Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.Semantic proximity Read ↗

Determination of loss of heterozygosity in frozen and paraffin embedded tumors by denaturating high-performance liquid chromatography (DHPLC).Semantic proximity Read ↗

Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinomaSemantic proximity Read ↗

Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.