Article
Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.
EBioMedicine - 1 Nov 2024
Zhang Xiaonan, Rameika Natallia, Zhong Lei, Rendo Verónica, Veanes Margus, Kundu Snehangshu, Nuciforo Sandro, Dupuis Jordan, Al Azhar Muhammad, Tsiara Ioanna, Seeburger Pauline, Al Nassralla Shahed, Ljungström Viktor, Svensson Richard, Stoimenov Ivaylo, Artursson Per, Heim Markus H, Globisch Daniel, Sjöblom Tobias
Abstract excerpt
BACKGROUND: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele. This can result in deficiency of specific protein activities in cancer cells, creating unique differences between tumour cells and normal cells of the individual. Such...
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