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Article

Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme.

Neurosurgery - 1 Nov 2006

Simon Matthias, Ludwig Michael, Fimmers Rolf, Mahlberg Ralph, Müller-Erkwoh Angelika, Köster Gertraud, Schramm Johannes

Abstract excerpt

OBJECTIVE: Germline mutations of the CHEK2 tumor suppressor gene have been found in families with the Li-Fraumeni syndrome (LFS). Patients with LFS experience a variety of cancers, including malignant astrocytomas. We investigated a potential role for a CHEK2 gene polymorphism in glioblastomas. M...

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Source

Identifiers

PMID: 17016233
DOI: 10.1227/01.NEU.0000245590.08463.5B

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17016233-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiforme.PMID 17016233Read ↗

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The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotypeSemantic proximity Read ↗

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