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Article

Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin.

Molecular and cellular biology - 1 Feb 2014

Zhang Shu-Min, Gao Lu, Zhang Xiao-Fei, Zhang Ran, Zhu Li-Hua, Wang Pi-Xiao, Tian Song, Yang Da, Chen Ke, Huang Ling, Zhang Xiao-Dong, Li Hongliang

Abstract excerpt

Interferon regulatory factor 8 (IRF8), a member of the IRF transcription factor family, was recently implicated in vascular diseases. In the present study, using the mouse left carotid artery wire injury model, we unexpectedly observed that the expression of IRF8 was greatly enhanced in smooth muscle cells (SMCs) by injury. Compared with the wild-type controls, IRF8 global knockout mice exhibited reduced...

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PMID: 24248596
DOI: 10.1128/MCB.01070-13
PMCID: PMC3911522

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