Article
RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis.
Cell proliferation - 1 May 2021
Li Yinan, Guo Xiangjiang, Xue Guanhua, Wang Han, Wang Yuli, Wang Weilun, Yang Shuofei, Ni Qihong, Chen Jiaquan, Lv Lei, Zhao Yiping, Ye Meng, Zhang Lan
Abstract excerpt
BACKGROUND: Vascular smooth muscle cells (VSMC) switch to macrophage-like cells after cholesterol loading, and this change may play an important role in atherogenesis. Muscleblind-like splicing regulator 1 (MBNL1) is a well-known splicing factor that has been implicated in many cellular processes. However, the role of MBNL1 in VSMC macrophage-like transdifferentiation is largely unknown. In this study, we aim to...
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