Article
A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus.
Genes & development - 15 May 2016
Beccari Leonardo, Yakushiji-Kaminatsui Nayuta, Woltering Joost M, Necsulea Anamaria, Lonfat Nicolas, Rodríguez-Carballo Eddie, Mascrez Benedicte, Yamamoto Shiori, Kuroiwa Atsushi, Duboule Denis
Abstract excerpt
During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets of Hoxd targets, first into the arm and subsequently into the digits. We studied the transition between these two global regulations, a switch that correlates...
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