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Article

Development of five digits is controlled by a bipartite long-range cis-regulator.

Development (Cambridge, England) - 1 Apr 2014

Lettice Laura A, Williamson Iain, Devenney Paul S, Kilanowski Fiona, Dorin Julia, Hill Robert E

Abstract excerpt

Conservation within intergenic DNA often highlights regulatory elements that control gene expression from a long range. How conservation within a single element relates to regulatory information and how internal composition relates to function is unknown. Here, we examine the structural features of the highly conserved ZRS (also called MFCS1) cis-regulator responsible for the spatiotemporal control of Shh in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24715461
DOI: 10.1242/dev.095430
PMCID: PMC3978833

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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