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Article

Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes.

Pharmacogenetics and genomics - 1 Nov 2005

Lazarus Philip, Zheng Yan, Runkle E Aaron, Muscat Joshua E, Wiener Doris

Abstract excerpt

The nicotine-derived tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is one of the most potent and abundant procarcinogens found in tobacco and tobacco smoke, and glucuronidation of its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), is...

Read the complete abstract on PubMed

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Share to Glucuronates
Share to Glucuronosyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsomes, Liver

Share to Minor Histocompatibility Antigens

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Source

Identifiers

PMID: 16220109
DOI: 10.1097/01.fpc.0000175596.52443.ef

Genes

UGT2B17
UGT2B7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16220109-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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