Article
Immunogenicity of single versus mixed allele vaccines of Plasmodium vivax Duffy binding protein region II.
Vaccine - 13 Sept 2013
Ntumngia Francis B, Schloegel Jesse, McHenry Amy M, Barnes Samantha J, George Miriam T, Kennedy Sandra, Adams John H
Abstract excerpt
The Duffy binding protein (DBP) of Plasmodium vivax is vital for host erythrocyte invasion. DBP region II (DBPII) contains critical residues for receptor recognition and anti-DBPII antibodies have been shown to inhibit erythrocyte binding and invasion, thereby making the molecule an attractive vaccine candidate against P. vivax blood stages. Similar to other blood-stage antigens, allelic variation within the...
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