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Genetic polymorphism of Duffy binding protein in Pakistan Plasmodium vivax isolates.

Acta tropica - 1 Dec 2024

Nguyễn Đăng Thùy Dương, Võ Tuấn Cường, Nguyễn Kim Oanh, Lê Hương Giang, Kang Jung-Mi, Nguyễn Thu Hằng, Cho Minkyoung, Afridi Sahib Gul, Na Byoung-Kuk

Abstract excerpt

Plasmodium vivax Duffy binding protein (PvDBP) is crucial for erythrocyte invasion, interacting with the Duffy Antigen Receptor for Chemokines (DARC) on the erythrocyte surface. The amino-terminal cysteine-rich region II of PvDBP (PvDBPII) is a promising blood stage vaccine candidate, yet the genetic polymorphisms of this protein in global P. vivax isolates complicate the design of effective vaccines against...

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PMID: 39357565
DOI: 10.1016/j.actatropica.2024.107421

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