Article
Prominence of NUDT15 genetic variation associated with 6-mercaptopurine tolerance in a genome-wide association study of Japanese children with acute lymphoblastic leukaemia.
British journal of haematology - 1 Oct 2022
Tanaka Yoichi, Urayama Kevin Y, Mori Makiko, Arakawa Yuki, Hasegawa Daisuke, Noguchi Yasushi, Yanagimachi Masakatsu, Keino Dai, Ota Setsuo, Akahane Koshi, Inukai Takeshi, Hangai Mayumi, Kawaguchi Takahisa, Takagi Masatoshi, Koh Katsuyoshi, Matsuda Fumihiko, Manabe Atsushi
Abstract excerpt
Inherited genetic variation is associated with 6-mercaptopurine (6-MP) dose reduction and frequent toxicities induced by 6-MP. However, the tolerable dose for 6-MP is not fully predicted by the known variation in NUDT15 and TPMT among Asian children with acute lymphoblastic leukaemia (ALL). We performed a genome-wide association study (GWAS) related to 6-MP dose among Japanese children with ALL. This GWAS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.