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Article

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1

21 Apr 2020

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a pivotal process in development and disease. In carcinogenesis, various signaling pathways are known to trigger EMT by inducing the expression of EMT transcription factors (EMT-TFs) like SNAIL1, ultimately promoting invasion, metastasis and chemoresistance. However, how EMT is executed downstream of EMT-TFs is incompletely understood. Here, using human colorectal cancer...

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PMID: 32326239
DOI: 10.3390/cancers12041019

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