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Article

In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma.

Cancer research - 1 Oct 2006

Rees Jonathan R E, Onwuegbusi Benjamin A, Save Vicki E, Alderson Derek, Fitzgerald Rebecca C

Abstract excerpt

There is increasing evidence that epithelial to mesenchymal transition (EMT) is involved in cancer progression. Because local invasion and metastasis occurs early in the pathogenesis of esophageal adenocarcinoma, we hypothesized that EMT may be important in this disease. Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin...

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Source

Identifiers

PMID: 17018615
DOI: 10.1158/0008-5472.CAN-06-1842

Genes

BMP7
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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