Article
Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.
PloS one - 1 Jan 2016
Momcilovic Olga, Sivapatham Renuka, Oron Tal Ronnen, Meyer Morten, Mooney Sean, Rao Mahendra S, Zeng Xianmin
Abstract excerpt
We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson's disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight of these lines (one of each SNCA, LRRK2 and GBA, four PARK2 lines, and the control) were differentiated into neural stem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.