Article
Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes.
Molecular biology and evolution - 1 Jun 2017
Buckley Matthew T, Racimo Fernando, Allentoft Morten E, Jensen Majken K, Jonsson Anna, Huang Hongyan, Hormozdiari Farhad, Sikora Martin, Marnetto Davide, Eskin Eleazar, Jørgensen Marit E, Grarup Niels, Pedersen Oluf, Hansen Torben, Kraft Peter, Willerslev Eske, Nielsen Rasmus
Abstract excerpt
FADS genes encode fatty acid desaturases that are important for the conversion of short chain polyunsaturated fatty acids (PUFAs) to long chain fatty acids. Prior studies indicate that the FADS genes have been subjected to strong positive selection in Africa, South Asia, Greenland, and Europe. By comparing FADS sequencing data from present-day and Bronze Age (5-3k years ago) Europeans, we identify possible...
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