Article

Probing Altered Receptor Specificities of Antigenically Drifting Human H3N2 Viruses by Chemoenzymatic Synthesis, NMR and Modeling

2023-04-05

Abstract excerpt

Prototypic receptors for human influenza viruses are cell surface N -glycans carrying α2,6-linked sialosides. Under immune pressure, A/H3N2 influenza viruses have emerged with altered receptor specificities that appear to recognize α2,6-linked sialosides presented on extended N -acetyl-lactosamine (LacNAc) moieties. Here, molecular recognition features of such drifted hemagglutinin’s (HAs) are examined by chemoe...

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Literature Corpus work: 12dd8216-b117-50c3-bbf0-c65a472e285a
DOI: 10.1101/2023.04.05.535696

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