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Article

Selection of Amikacin Hyper-Resistant Pseudomonas aeruginosa After Stepwise Exposure to High Amikacin Concentrations.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2017

Amábile-Cuevas Carlos F

Abstract excerpt

Aerosolized amikacin reaches high concentrations in lung fluids, which are well above the minimum inhibitory concentrations (MICs) of resistant strains of Pseudomonas aeruginosa. However, P. aeruginosa can gain resistance to amikacin through different cumulative mechanisms; amikacin MICs are seldom reported beyond values of 1,000 μg/ml, as tested in clinical microbiology assays. To assess how high amikacin MICs...

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PMID: 27183474
DOI: 10.1089/mdr.2015.0218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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