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Article

Evolution of the Pseudomonas aeruginosa Aminoglycoside Mutational Resistome In Vitro and in the Cystic Fibrosis Setting.

Antimicrobial agents and chemotherapy - 1 Apr 2018

López-Causapé Carla, Rubio Rosa, Cabot Gabriel, Oliver Antonio

Abstract excerpt

Inhaled administration of high doses of aminoglycosides is a key maintenance treatment of Pseudomonas aeruginosa chronic respiratory infections in cystic fibrosis (CF). We analyzed the dynamics and mechanisms of stepwise high-level tobramycin resistance development in vitro and compared the results with those of isogenic pairs of susceptible and resistant clinical isolates. Resistance development correlated with...

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Identifiers

PMID: 29437613
DOI: 10.1128/AAC.02583-17
PMCID: PMC5913951

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