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Mechanisms responsible for imipenem resistance among Pseudomonas aeruginosa clinical isolates exposed to imipenem concentrations within the mutant selection window.

Diagnostic microbiology and infectious disease - 1 Jul 2017

Vassilara Foula, Galani Irene, Souli Maria, Papanikolaou Konstantinos, Giamarellou Helen, Papadopoulos Antonios

Abstract excerpt

The aim of this study was to determine the propensities of imipenem to select for resistant Pseudomonas aeruginosa mutants by determining the mutant prevention concentrations (MPCs) for 9 unrelated clinical isolates and the accession of any relationship with mechanisms of resistance development. The MPC/MIC ratios ranged from 4 to 16. Detection of resistance mechanisms in the mutant derivatives of the nine...

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PMID: 28434899
DOI: 10.1016/j.diagmicrobio.2017.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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