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Article

Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar.

Scientific reports - 16 May 2016

Su Linlin, Li Xiaodong, Wu Xue, Hui Bo, Han Shichao, Gao Jianxin, Li Yan, Shi Jihong, Zhu Huayu, Zhao Bin, Hu Dahai

Abstract excerpt

Hypertrophic scar (HS) is a serious fibrotic skin condition with currently no satisfactory therapy due to undefined molecular mechanism. FAK and Src are two important non-receptor tyrosine kinases that have been indicated in HS pathogenesis. Here we found both FAK and Src were activated in HS vs. normal skin (NS), NS fibroblasts treated with TGF-β1 also exhibited FAK/Src activation. Co-immunoprecipitation and...

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Identifiers

PMID: 27181267
DOI: 10.1038/srep26023
PMCID: PMC4867599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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