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Article

Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling

4 Oct 2019

Abstract excerpt

Biomechanical force and pathological angiogenesis are dominant features in fibro-proliferative disorders. Understanding the role and regulation of the mechanical microenvironment in which pathological angiogenesis occurs is an important challenge when investigating numerous angiogenesis-related diseases. In skin fibrosis, dermal fibroblasts and vascular endothelial cells are integral to hypertrophic scar...

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PMID: 31602408
DOI: 10.1038/s42003-019-0600-6

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