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Article

Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes.

Experimental dermatology - 1 Feb 2016

Li Bing, Gao Chao, Diao Jian-Sheng, Wang Da-Lei, Chu Fei-Fei, Li Yang, Wang Gang, Guo Shu-Zhong, Xia Wei

Abstract excerpt

Hypertrophic scar (HS) is characterized by fibroblast hyperproliferation and excessive matrix deposition. Aberrant keratinocyte differentiation and their abnormal cytokine secretion are said to contribute to HS by activating fibroblasts. However, the signalling pathway causing the aberrant keratinocytes in HS has remained unidentified thus far. Given that Notch signalling is crucial in initiating keratinocyte...

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PMID: 26566963
DOI: 10.1111/exd.12897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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