Article
An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia.
Clinical pharmacology and therapeutics - 1 Mar 2017
Stock W, Diouf B, Crews K R, Pei D, Cheng C, Laumann K, Mandrekar S J, Luger S, Advani A, Stone R M, Larson R A, Evans W E
Abstract excerpt
Peripheral neuropathy is a major toxicity of vincristine, yet no strategies exist for identifying adult patients at high-risk. We used a case-control design of 48 adults receiving protocol therapy for acute lymphoblastic leukemia (ALL) who developed vincristine-induced neuropathy (NCI grade 2-4) during treatment, and 48 matched controls who did not develop grade 2-4 neuropathy. Peripheral neuropathy was...
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