Article
Lack of association of the CEP72 rs924607 TT genotype with vincristine-related peripheral neuropathy during the early phase of pediatric acute lymphoblastic leukemia treatment in a Spanish population.
Pharmacogenetics and genomics - 1 Feb 2016
Gutierrez-Camino Angela, Martin-Guerrero Idoia, Lopez-Lopez Elixabet, Echebarria-Barona Aizpea, Zabalza Iñaki, Ruiz Irune, Guerra-Merino Isabel, Garcia-Orad Africa
Abstract excerpt
Vincristine is a component of acute lymphoblastic leukemia (ALL) treatment with the potential to induce peripheral neuropathy. Recently, the CEP72 rs924607 TT genotype was found to be associated with vincristine-induced toxicity during the continuation phase in pediatric ALL patients treated on the Total XIIIB and COG AALL0433 protocols at St Jude Children's Research Hospital and Children's Oncology Group. This...
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