Article
Mannose-binding lectin gene (MBL2) polymorphisms related to the mannose-binding lectin low levels are associated to dengue disease severity.
Human immunology - 1 Jul 2016
Figueiredo Gabriela G, Cezar Renata D, Freire Naishe M, Teixeira Vanessa G, Baptista Paulo, Cordeiro Marli, Carmo Rodrigo F, Vasconcelos Luydson Richardson Silva, Moura Patrícia
Abstract excerpt
Dengue is the main arbovirosis in the tropical and subtropical areas of the world. The majority of infected individuals present an asymptomatic outcome while others progress to dengue fever (DF) or dengue haemorrhagic fever (DHF). Dengue infection evolution to severe outcomes is in part, related to innate immunity response. The MBL2 gene encodes for a pathogen recognition pattern molecule, the mannose-binding...
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