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Mannose-binding lectin levels and MBL2 gene polymorphisms are associated with dengue infection in Brazilian children at the early ages.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2022

Sena Marília A, da Silva Castanha Priscila Mayrelle, Giles Guimarães Ana Beatriz, Oliveira Paula Alexandra Dos Santos, da Silva Maria Almerice Lopes, Cordeiro Marli Tenório, Moura Patricia, Braga Cynthia, Vasconcelos Luydson Richardson Silva

Abstract excerpt

BACKGROUND: The mannose-binding lectin (MBL) plays an important role in innate immunity. Genetically determined variations in serum levels of MBL may influence the susceptibility and clinical outcome of dengue infection in early life. METHODS: We investigated the MBL2 gene polymorphisms and serum levels of MBL (total and functional) in children with asymptomatic (n=17) and symptomatic (n=29) primary dengue...

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PMID: 35150914
DOI: 10.1016/j.ijid.2022.02.012

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