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Article

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

7 Feb 2018

Abstract excerpt

Abstract Cancer-initiating cells (CICs) are responsible for tumor initiation, progression, and therapeutic resistance; moreover, redox homeostasis is important in regulating cancer stemness. Previously, we have identified that cancer cells containing low intracellular reactive oxygen species levels (ROS Low cells) display enhanced features of CICs. However, the specific metabolic signatures of CICs remain unclear...

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PMID: 29416012
DOI: 10.1038/s41419-017-0250-x

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