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Article

Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus.

PloS one - 1 Jan 2015

Hargreaves Chantal E, Iriyama Chisako, Rose-Zerilli Matthew J J, Nagelkerke Sietse Q, Hussain Khiyam, Ganderton Rosalind, Lee Charlotte, Machado Lee R, Hollox Edward J, Parker Helen, Latham Kate V, Kuijpers Taco W, Potter Kathleen N, Coupland Sarah E, Davies Andrew, Stackpole Michael, Oates Melanie, Pettitt Andrew R, Glennie Martin J, Cragg Mark S, Strefford Jonathan C

Abstract excerpt

Cancer immunotherapy has been revolutionised by the use monoclonal antibodies (mAb) that function through their interaction with Fc gamma receptors (FcγRs). The low-affinity FcγR genes are highly homologous, map to a complex locus at 1p23 and harbour single nucleotide polymorphisms (SNPs) and copy number variation (CNV) that can impact on receptor function and response to therapeutic mAbs. This complexity can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

Share to Multiplex Polymerase Chain Reaction

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Source

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Identifiers

PMID: 26545243
DOI: 10.1371/journal.pone.0142379
PMCID: PMC4636148

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