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Article

Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.

Genes and immunity - 1 Sept 2015

Nagelkerke S Q, Tacke C E, Breunis W B, Geissler J, Sins J W R, Appelhof B, van den Berg T K, de Boer M, Kuijpers T W

Abstract excerpt

The human FCGR2/3 locus, containing five highly homologous genes encoding the major IgG receptors, shows extensive copy number variation (CNV) associated with susceptibility to autoimmune diseases. Having genotyped >4000 individuals, we show that all CNV at this locus can be explained by nonallelic homologous recombination (NAHR) of the two paralogous repeats that constitute the majority of the locus, and...

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Identifiers

PMID: 26133275
DOI: 10.1038/gene.2015.25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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