Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.

doi:10.1038/ejhg.2015.95

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Article

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.

European journal of human genetics : EJHG - 1 Feb 2016

Franke Lude, el Bannoudi Hanane, Jansen Diahann T S L, Kok Klaas, Trynka Gosia, Diogo Dorothee, Swertz Morris, Fransen Karin, Knevel Rachel, Gutierrez-Achury Javier, Ärlestig Lisbeth, Greenberg Jeffrey D, Kremer Joel, Pappas Dimitrios A, Kanterakis Alexandros, Weersma Rinse K, van der Helm-van Mil Annette H M, Guryev Viktor, Rantapää-Dahlqvist Solbritt, Gregersen Peter K, Plenge Robert M, Wijmenga Cisca, Huizinga Tom W-J, Ioan-Facsinay Andreea, Toes Rene E M, Zhernakova Alexandra

Abstract excerpt

Segmental duplications (SDs) comprise about 5% of the human genome and are enriched for immune genes. SD loci often show copy numbers variations (CNV), which are difficult to tag with genotyping methods. CNV in the Fcγ receptor region (FCGR) has been suggested to be associated with rheumatic diseases. The objective of this study was to delineate association of FCGR-CNV with rheumatoid arthritis (RA), coeliac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25966632
DOI: 10.1038/ejhg.2015.95
PMCID: PMC4717214

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