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Article

MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma.

Oncotarget - 14 Jun 2016

Miller Michael B, Bi Wenya Linda, Ramkissoon Lori A, Kang Yun Jee, Abedalthagafi Malak, Knoff David S, Agarwalla Pankaj K, Wen Patrick Y, Reardon David A, Alexander Brian M, Laws Edward R, Dunn Ian F, Beroukhim Rameen, Ligon Keith L, Ramkissoon Shakti H

Abstract excerpt

Pituitary spindle cell oncocytoma (SCO) is an uncommon primary pituitary neoplasm that presents with mass effect on adjacent neurovascular structures, similar to non-hormone-producing pituitary adenomas. To determine the molecular etiology of SCO, we performed exome sequencing on four SCO cases, with matched normal controls, to assess somatic mutations and copy number alterations. Our analysis revealed a low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27175596
DOI: 10.18632/oncotarget.9244
PMCID: PMC5095058

Genes

HRAS
FAT1
MEN1
SND1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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