Article
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
Nature genetics - 1 Feb 2013
Chmielecki Juliann, Crago Aimee M, Rosenberg Mara, O'Connor Rachael, Walker Sarah R, Ambrogio Lauren, Auclair Daniel, McKenna Aaron, Heinrich Michael C, Frank David A, Meyerson Matthew
Abstract excerpt
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
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