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Article

Non-recurrent mutations and copy number changes predominate pituitary adenoma genomes.

European journal of endocrinology - 30 Apr 2025

Mohan Dipika R, Paes Ticiana, Buelvas Mebarak Jacobo, Meredith David M, Soares Beatriz, Vaz Victor, Carroll Rona S, Kaiser Ursula B, Smith Timothy R, Bi Wenya L, Lerario Antonio M, Abreu Ana Paula

Abstract excerpt

OBJECTIVE: Pituitary adenomas (PAs) are common neoplasms. Our current understanding of the molecular basis of PA formation is incomplete. Routine implementation of targeted genomics has enabled the discovery of rare, potentially clinically actionable events. METHODS: We used a cancer-focused gene panel to sequence a cohort of 171 PAs from patients who underwent surgery at Brigham and Women's Hospital from 2012 to...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endopeptidases

Share to Endosomal Sorting Complexes Required for Transport

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Open in PubMed Open full text

Identifiers

PMID: 40300997
DOI: 10.1093/ejendo/lvaf086
PMCID: PMC13138838

Genes

GNAS
MEN1
MIB1
USP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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