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Cortisol-Producing Oncocytic Adrenocortical Carcinoma Harboring a GNAS Mutation: An Integrated Histologic, Ultrastructural, and Genomic Analysis.

Pathology international - 1 Apr 2026

Sato Naomi, Tezuka Yuta, Itoh Taito, Omori Yuko, Koike Taro, Satou Masaki, Ogata Masaki, Ono Yoshikiyo, Kitada Masaaki, Yamazaki Yuto, Furukawa Toru, Suzuki Takashi, Nakamura Yasuhiro

Abstract excerpt

Oncocytic adrenal neoplasms are rare adrenocortical tumors characterized by abundant eosinophilic cytoplasm due to massive mitochondrial accumulation. Their biological behavior is often difficult to predict, and various diagnostic systems-including the Lin-Weiss-Bisceglia system, the Helsinki score, and the reticulin algorithm-are used to assess their malignant potential. We report a case of an oncocytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41936040
DOI: 10.1111/pin.70112

Genes

GNAS
ARID1A
CDKN2A
ZNRF3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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