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Article

Chromosomal alteration patterns in PitNETs: massive losses in aggressive tumors.

Endocrine-related cancer - 1 Jan 2025

Jentus Maaia Margo, Bakker Leontine, Verstegen Marco, Pelsma Iris, van Wezel Tom, Ruano Dina, Kapiteijn Ellen, Crobach Stijn, Biermasz Nienke, Morreau Hans

Abstract excerpt

The molecular biology of pituitary neuroendocrine tumors (PitNETs) revealed few recurrent mutations and extensive chromosomal alterations, with the latter being the driving force in a subset of these lesions. Addressing the need for an easily applicable diagnostic tool, we conducted a retrospective study of 61 PitNETs operated at a tertiary care center. All cases were subtyped according to the 2022 WHO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39441837
DOI: 10.1530/ERC-24-0070
PMCID: PMC11729050

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