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Article

Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

13 May 2016

Abstract excerpt

The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV...

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PMID: 27174054
DOI: 10.1038/cr.2016.58

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