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Zika virus impairs the development of blood vessels in a mouse model of congenital infection

20 Aug 2018

Abstract excerpt

Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in brain growth. Here we demonstrated in vivo the impact of congenital ZIKV infection in blood vessel development, a crucial step in organogenesis. ZIKV was injected intravenously in the pregnant type 2 interferon (IFN)-deficient mouse at embryonic day (E) 12.5. The embryos were collected at E15.5...

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PMID: 30143723
DOI: 10.1038/s41598-018-31149-3

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