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Replication of early and recent Zika virus isolates throughout mouse brain development

31 Oct 2017

Abstract excerpt

Fetal infection with Zika virus (ZIKV) can lead to congenital Zika virus syndrome (cZVS), which includes cortical malformations and microcephaly. The aspects of cortical development that are affected during virus infection are unknown. Using organotypic brain slice cultures generated from embryonic mice of various ages, sites of ZIKV replication including the neocortical proliferative zone and radial columns, as...

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PMID: 29087938
DOI: 10.1073/pnas.1714624114

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