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Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage

12 Oct 2016

Abstract excerpt

Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic microcephaly. However, the fate of other cell types in the developing brain and their contributions to ZIKV-associated brain abnormalities remain largely unknown. Using intracerebral inoculation of embryonic mouse brains, we found...

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PMID: 27729407
DOI: 10.1242/dev.143768

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