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Article

Role of microglia in the dissemination of Zika virus from mother to fetal brain

6 Jul 2020

Abstract excerpt

Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical transmission. We found that embryonic (E) days 6.5-E8.5 were a critical window for ZIKV infection that resulted in...

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PMID: 32628667
DOI: 10.1371/journal.pntd.0008413

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